Perez-Meza David, Ziering Craig, Sforza Marcos, Krishnan Ganesh, Ball Edward, Daniels Eric
Ziering Medical, Marbella, Spain.
Ziering Medical, Los Angeles, CA, USA.
Stem Cells Cloning. 2017 Jul 6;10:1-10. doi: 10.2147/SCCAA.S131431. eCollection 2017.
Great interest remains in finding new and emerging therapies for the treatment of male and female pattern hair loss. The autologous fat grafting technique is >100 years old, with a recent and dramatic increase in clinical experience over the past 10-15 years. Recently, in 2001, Zuk et al published the presence of adipose-derived stem cells, and abundant research has shown that adipose is a complex, biological active, and important tissue. Festa et al, in 2011, reported that adipocyte lineage cells support the stem cell niche and help drive the complex hair growth cycle. Adipose-derived regenerative cells (also known as stromal vascular fraction [SVF]) is a heterogeneous group of noncultured cells that can be reliably extracted from adipose by using automated systems, and these cells work largely by paracrine mechanisms to support adipocyte viability. While, today, autologous fat is transplanted primarily for esthetic and reconstructive volume, surgeons have previously reported positive skin and hair changes posttransplantation. This follicular regenerative approach is intriguing and raises the possibility that one can drive or restore the hair cycle in male and female pattern baldness by stimulating the niche with autologous fat enriched with SVF. In this first of a kind patient series, the authors report on the safety, tolerability, and quantitative, as well as photographic changes, in a group of patients with early genetic alopecia treated with subcutaneous scalp injection of enriched adipose tissue. The findings suggest that scalp stem cell-enriched fat grafting may represent a promising alternative approach to treating baldness in men and women.
寻找治疗男性和女性型脱发的新疗法仍然备受关注。自体脂肪移植技术已有100多年历史，在过去10至15年中临床经验有了显著增加。2001年，祖克等人发表了脂肪来源干细胞的研究成果，大量研究表明脂肪是一种复杂、具有生物活性且重要的组织。2011年，费斯塔等人报告称脂肪细胞系细胞支持干细胞微环境并有助于推动复杂的头发生长周期。脂肪来源的再生细胞（也称为基质血管成分[SVF]）是一组异质性的未培养细胞，可以通过自动化系统从脂肪中可靠地提取出来，这些细胞主要通过旁分泌机制来支持脂肪细胞的存活。如今，自体脂肪主要用于美容和重建性填充，但外科医生此前曾报告过移植后皮肤和头发有积极变化。这种毛囊再生方法很有趣，并且提出了一种可能性，即通过用富含SVF的自体脂肪刺激微环境，可以驱动或恢复男性和女性型秃发中的头发生长周期。在这个首例患者系列中，作者报告了一组早期遗传性脱发患者经皮下头皮注射富含脂肪组织后的安全性、耐受性、定量以及照片变化情况。研究结果表明，富含头皮干细胞的脂肪移植可能是治疗男性和女性脱发的一种有前景的替代方法。
