Fessler Evelyn, Medema Jan Paul
Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center (AMC), Amsterdam 1105 AZ, The Netherlands; Cancer Center Amsterdam (CCA), Amsterdam, The Netherlands; Cancer Genomics Center, Utrecht, The Netherlands.
Laboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental and Molecular Medicine (CEMM), Academic Medical Center (AMC), Amsterdam 1105 AZ, The Netherlands; Cancer Center Amsterdam (CCA), Amsterdam, The Netherlands; Cancer Genomics Center, Utrecht, The Netherlands.
Trends Cancer. 2016 Sep;2(9):505-518. doi: 10.1016/j.trecan.2016.07.008. Epub 2016 Sep 3.
Cancer is a heterogeneous disease and many cancer types do not represent a single entity, but are composed of biologically and clinically diverse subtypes. The subtype affiliation can influence prognosis and response to therapy. Recently, a multicenter colorectal cancer (CRC) subtyping consortium introduced a consensus molecular classification system for CRC. This will be of great benefit for future basic and clinical research since it enables uniform categorization of CRC specimens across different institutes and studies. The biological conformity observed within each consensus molecular subtype (CMS) holds promise for the design of subtype-specific treatment regimens. Herein, we review the CMSs of CRC with a focus on how multiple parameters, such as the origin, developmental route, and microenvironmental regulation shape distinct subtypes.
癌症是一种异质性疾病，许多癌症类型并非单一实体，而是由生物学和临床特征各异的亚型组成。亚型归属会影响预后及对治疗的反应。最近，一个多中心结直肠癌（CRC）分型联盟推出了一种CRC的共识分子分类系统。这将对未来的基础和临床研究大有裨益，因为它能对不同机构和研究中的CRC标本进行统一分类。在每个共识分子亚型（CMS）中观察到的生物学一致性为设计亚型特异性治疗方案带来了希望。在此，我们综述CRC的CMS，重点关注多个参数，如起源、发育途径和微环境调控如何塑造不同的亚型。
