Thanki Ketan, Nicholls Michael E, Gajjar Aakash, Senagore Anthony J, Qiu Suimin, Szabo Csaba, Hellmich Mark R, Chao Celia
Department of Surgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Department of Surgical Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Int Biol Biomed J. 2017 Summer;3(3):105-111. Epub 2017 Jun 13.
The colorectal cancer (CRC) Subtyping Consortium has unified six independent molecular classification systems, based on gene expression data, into a single consensus system with four distinct groups, known as the Consensus Molecular Subtypes (CMS); clinical implications are discussed in this review. This article is based on a literature review relevant to the CMS of CRC indexed in PubMed (US National Library of Medicine) as well as the authors' own published data. The CMS were determined and correlated with epigenomic, transcriptomic, microenvironmental, genetic, prognostic and clinical characteristics. The CMS1 subtype is immunogenic and hypermutated. CMS2 tumors are activated by the WNT-β-catenin pathway and have the highest overall survival. CMS3 feature a metabolic cancer phenotype and CMS4 cancers have the worst survival and have a strong stromal gene signature. The Consensus Molecular Subtypes of CRC may better inform clinicians of prognosis, therapeutic response, and potential novel therapeutic strategies.
结直肠癌（CRC）亚型联盟已将基于基因表达数据的六个独立分子分类系统统一为一个具有四个不同组的单一共识系统，即共识分子亚型（CMS）；本综述讨论了其临床意义。本文基于对美国国立医学图书馆PubMed中索引的与CRC的CMS相关的文献综述以及作者自己发表的数据。确定了CMS，并将其与表观基因组、转录组、微环境、遗传、预后和临床特征相关联。CMS1亚型具有免疫原性且高度突变。CMS2肿瘤由WNT-β-连环蛋白途径激活，总体生存率最高。CMS3具有代谢性癌症表型，CMS4癌症的生存率最差，且具有强烈的基质基因特征。CRC的共识分子亚型可能会更好地为临床医生提供有关预后、治疗反应和潜在新治疗策略的信息。
