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重新审视淋巴管与抗肿瘤免疫

Rethinking Lymphatic Vessels and Antitumor Immunity.

作者信息

Lund Amanda W

机构信息

Department of Cell, Developmental, & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

出版信息

Trends Cancer. 2016 Oct;2(10):548-551. doi: 10.1016/j.trecan.2016.09.005. Epub 2016 Sep 24.

Abstract

Lymphatic vessels facilitate fluid homeostasis, immune cell trafficking, and lipid transport, and contribute to solid tumor progression as routes of metastasis. Given new evidence that lymphatic vessels both correlate with intratumoral lymphocytes and directly suppress immune function, I reevaluate the passive lymphatic vessel paradigm and discuss its relevance to antitumor immunity.

摘要

淋巴管有助于维持液体稳态、免疫细胞运输和脂质转运,并作为转移途径促进实体瘤进展。鉴于新证据表明淋巴管既与肿瘤内淋巴细胞相关,又直接抑制免疫功能,我重新评估了被动淋巴管范式,并讨论了其与抗肿瘤免疫的相关性。

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