Laboratory of Autoimmunity, Division of Experimental Pathophysiology and Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria,
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden,
Gerontology. 2020;66(5):419-426. doi: 10.1159/000508459. Epub 2020 Jun 24.
The lymphatic system is responsible for fluid drainage from almost every organ in the body. It sustains tissue homeostasis and is also a central part of the immune system. With the discovery of cell-specific markers and transgenic mouse models, it has become possible to gain some insight into the developmental and functional roles of lymphatic endothelial cells (LECs). Only recently, a more direct regulatory role has been assigned to LECs in their functions in immunity responses and chronic diseases. Here, we discuss the changes occurring in aged lymphatic system and the role of lymphatic capillaries in some age-related diseases and experimental animal models.
淋巴系统负责从体内几乎每个器官中排出液体。它维持组织内环境稳定，也是免疫系统的核心部分。随着细胞特异性标记物和转基因小鼠模型的发现，人们已经能够深入了解淋巴管内皮细胞（LEC）的发育和功能作用。直到最近，LEC 在免疫反应和慢性疾病中的功能才被赋予了更直接的调节作用。在这里，我们讨论了衰老的淋巴系统中发生的变化，以及淋巴管在一些与年龄相关的疾病和实验动物模型中的作用。
