Cyrus Tang Hematology Center, Collaborative Innovation Center of Hematology, the Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and the Chinese Ministry of Science and Technology, Soochow University, 199 Ren'ai Rd, Suzhou 215123, China.
Departments of Neurosurgery, Cancer Biology and Neuroscience, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, Florida 32224, USA.
Nat Rev Immunol. 2018 Mar;18(3):195-203. doi: 10.1038/nri.2017.145. Epub 2018 Jan 15.
The vasculature of tumours is highly abnormal and dysfunctional. Consequently, immune effector cells have an impaired ability to penetrate solid tumours and often exhibit compromised functions. Normalization of the tumour vasculature can enhance tissue perfusion and improve immune effector cell infiltration, leading to immunotherapy potentiation. However, recent studies have demonstrated that the stimulation of immune cell functions can also help to normalize tumour vessels. In this Opinion article, we propose that the reciprocal regulation between tumour vascular normalization and immune reprogramming forms a reinforcing loop that reconditions the tumour immune microenvironment to induce durable antitumour immunity. A deeper understanding of these pathways could pave the way for identifying new biomarkers and developing more effective combination treatment strategies for patients with cancer.
肿瘤的脉管系统高度异常和功能失调。因此，免疫效应细胞穿透实体瘤的能力受损，功能常常受到损害。肿瘤脉管系统的正常化可以增强组织灌注并改善免疫效应细胞浸润，从而增强免疫治疗效果。然而，最近的研究表明，免疫细胞功能的刺激也有助于肿瘤血管的正常化。在这篇观点文章中，我们提出，肿瘤血管正常化和免疫重编程之间的相互调节形成了一个增强回路，使肿瘤免疫微环境重新形成，从而诱导持久的抗肿瘤免疫。深入了解这些途径可能为识别新的生物标志物和为癌症患者开发更有效的联合治疗策略铺平道路。
