Institute of Bioengineering and Swiss Institute of Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
J Mammary Gland Biol Neoplasia. 2010 Sep;15(3):341-52. doi: 10.1007/s10911-010-9193-x. Epub 2010 Sep 11.
Research in lymphatic biology and cancer immunology may soon intersect as emerging evidence implicates the lymphatics in the progression of chronic inflammation and autoimmunity as well as in tumor metastasis and immune escape. Like the blood vasculature, the lymphatic system comprises a highly dynamic conduit system that regulates fluid homeostasis, antigen transport and immune cell trafficking, which all play important roles in the progression and resolution of inflammation, autoimmune diseases, and cancer. This review presents emerging evidence that lymphatic vessels are active modulators of immunity, perhaps fine-tuning the response to adjust the balance between peripheral tolerance and immunity. This suggests that the tumor-associated lymphatic vessels and draining lymph node may be important in tumor immunity which in turn governs metastasis.
淋巴生物学和癌症免疫学的研究可能很快会交叉，因为新出现的证据表明，淋巴管在慢性炎症和自身免疫的进展中，以及在肿瘤转移和免疫逃逸中起作用。像血管系统一样，淋巴系统包括一个高度动态的导管系统，调节体液平衡、抗原运输和免疫细胞运输，所有这些在炎症、自身免疫性疾病和癌症的进展和消退中都起着重要作用。这篇综述提出了新的证据，表明淋巴管是免疫的活跃调节剂，可能微调了反应，以调整外周耐受和免疫之间的平衡。这表明，肿瘤相关的淋巴管和引流淋巴结在肿瘤免疫中可能很重要，而肿瘤免疫反过来又控制着转移。
