Grimstad Frances W, Decherney Alan
*Department of Obstetrics and Gynecology, University of Kansas Medical Center, Lawrence, Kansas †Reproductive and Adult Endocrinology/Reproductive Biology and Medicine Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) of the National Institutes of Health, Bethesda, Maryland.
Clin Obstet Gynecol. 2017 Sep;60(3):467-476. doi: 10.1097/GRF.0000000000000298.
Epigenetic influences have been postulated to affect the course of endometriosis. DNA methyltransferases, estrogen and progesterone receptors, micro-RNAs, and histone deacetylators, have shown differential expression in endometriosis compared with normal endometrium. Others such as aromatase, Steroid Factor-1, COX-2, and Homeobox A10 also have epigenetic modifications in endometriosis. Limitations in this area of research include heterogeneity in study design, patient populations, and methods of analysis. Larger, controlled studies are needed. Future targeted uses of this work may include using methylomes to noninvasively diagnose endometriosis, or targeting histone-deacetylase inhibitors for treatment.
表观遗传影响被假定会影响子宫内膜异位症的病程。与正常子宫内膜相比，DNA甲基转移酶、雌激素和孕激素受体、微小RNA以及组蛋白去乙酰化酶在子宫内膜异位症中表现出差异表达。其他如芳香化酶、类固醇因子-1、环氧化酶-2和同源盒A10在子宫内膜异位症中也有表观遗传修饰。该研究领域的局限性包括研究设计、患者群体和分析方法的异质性。需要开展更大规模的对照研究。这项工作未来的靶向应用可能包括利用甲基化组进行子宫内膜异位症的无创诊断，或靶向组蛋白去乙酰化酶抑制剂进行治疗。
