Chen Huixi, Malentacchi Francesca, Fambrini Massimiliano, Harrath Abdel Halim, Huang Hefeng, Petraglia Felice
Obstetrics and Gynecology Unit, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Reprod Sci. 2020 Nov;27(11):1967-1974. doi: 10.1007/s43032-020-00226-2. Epub 2020 Jul 22.
Endometriosis is an estrogen-dependent inflammatory gynecological disease. Increased estrogen activity and progesterone resistance are the main hormonal substrate of this disease and are associated with inflammatory response and debilitating symptoms, including pain and infertility. Estrogens and progesterone act via their specific nuclear receptors. The regulation of receptor expression by epigenetics maybe a critical factor for endometriosis. The present review aims to discuss the epigenetic mechanisms related to the expression of estrogen receptors (ERs) and progesterone receptors (PRs) in patients with endometriosis, including two classic epigenetic mechanisms: DNA methylation and histone modification, and, other non-classic mechanisms: miRNAs and lncRNA. Several in vitro and in vivo studies support the key role of epigenetics in the regulation of the expression of ERs and PRs, which may provide new molecules and targets for the diagnosis and treatment of endometriosis.
子宫内膜异位症是一种雌激素依赖性炎症性妇科疾病。雌激素活性增加和孕激素抵抗是该疾病的主要激素基础，且与炎症反应和使人衰弱的症状相关，包括疼痛和不孕。雌激素和孕激素通过其特定的核受体发挥作用。表观遗传学对受体表达的调控可能是子宫内膜异位症的一个关键因素。本综述旨在探讨与子宫内膜异位症患者雌激素受体（ERs）和孕激素受体（PRs）表达相关的表观遗传机制，包括两种经典的表观遗传机制：DNA甲基化和组蛋白修饰，以及其他非经典机制：微小RNA（miRNAs）和长链非编码RNA（lncRNA）。多项体外和体内研究支持表观遗传学在ERs和PRs表达调控中的关键作用，这可能为子宫内膜异位症的诊断和治疗提供新的分子和靶点。
