Department of Integrated Medical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, United States.
School of Integrated Science and Humanity, Florida International University, Miami, FL, United States.
J Psychiatr Res. 2017 Nov;94:180-185. doi: 10.1016/j.jpsychires.2017.07.011. Epub 2017 Jul 18.
Schizophrenia (SCZ) and bipolar disorder (BP) are linked to multiple impairments in everyday functioning which share cognitive and symptom risk factors. Other risk factors for critical aspects of every day functioning (e.g., gainful employment; residential independence) such as physical health have not been evaluated, despite poor health in SCZ and BP.
We analyzed 20-year follow-up data from the Suffolk County Mental Health Project cohort of consecutive first admissions with a psychotic disorder to 12 psychiatric facilities in Suffolk County, NY, between September 1989 and December 1995. Both 20-year symptom, health, and cognition data, and the 20-year course of weight gain were included as predictors of employment and residence status.
The analysis sample consisted of 122 participants with SCZ ad BP, with SCZ participants less likely to work or live independently. Correlational analyses showed symptoms and cognition predicted vocational outcomes in both samples. The effect of diagnosis was significant for both gainful employment and independence in residence. After consideration of diagnosis, mobility and negative symptoms predicted gainful employment in both samples, but there were no additional predictors of residential independence. Prospective analysis of BMI found that baseline BMI, but not changes during the 20-year follow up, predicted labor force participation.
Health status limitations were associated with residential and, particularly, employment status independent from other, previously established predictors of everyday outcomes, including cognition and symptoms. The importance of health status limitations for predicting outcome was confirmed in both SCZ and BP, with schizophrenia representing the more impaired group.
精神分裂症(SCZ)和双相情感障碍(BP)与日常功能的多种障碍有关,这些障碍共享认知和症状风险因素。其他与日常功能的重要方面(例如有酬就业;独立居住)相关的风险因素(例如身体健康)尚未得到评估,尽管 SCZ 和 BP 的健康状况不佳。
我们分析了来自纽约州萨福克县精神卫生项目队列的 20 年随访数据,该队列包括 1989 年 9 月至 1995 年 12 月期间在萨福克县 12 家精神病院连续首次入院的精神障碍患者。将 20 年的症状、健康和认知数据以及 20 年的体重增加情况作为就业和居住状况的预测指标。
分析样本包括 122 名 SCZ 和 BP 患者,SCZ 患者更不可能工作或独立居住。相关分析显示,症状和认知在两个样本中均预测职业结果。诊断的影响对两个样本的有酬就业和独立居住都有意义。在考虑诊断后,在两个样本中,移动性和阴性症状预测了有酬就业,但没有其他居住独立性的预测指标。BMI 的前瞻性分析发现,基线 BMI 而不是 20 年随访期间的变化,预测了劳动力参与。
健康状况的限制与居住状况有关,特别是与就业状况有关,与其他以前确定的日常结果预测因素(包括认知和症状)无关。健康状况限制对预后的重要性在 SCZ 和 BP 中均得到了证实,精神分裂症代表了更受损的群体。