Harvey Philip D, Bosia Marta, Cavallaro Roberto, Howes Oliver D, Kahn René S, Leucht Stefan, Müller Daniel R, Penadés Rafael, Vita Antonio
Division of Psychology, Department of Psychiatry, University of Miami Miller School of Medicine, Miami, FL, USA.
Vita-Salute San Raffaele University School of Medicine, Milan, Italy; Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute Hospital, Milan, Italy.
Schizophr Res Cogn. 2022 Mar 22;29:100249. doi: 10.1016/j.scog.2022.100249. eCollection 2022 Sep.
Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and functional recovery. This expert group paper brings together experts in schizophrenia treatment to discuss scientific progress in the domain of cognitive impairment to address cognitive impairments and their consequences in the most effective way. We report on the onset and course of cognitive deficits, linking them to the alterations in brain function and structure in schizophrenia and discussing their role in predicting the transition to psychosis in people at risk. We then address the assessment tools with reference to functioning and social cognition, examining the role of subjective measures and addressing new methods for measuring functional outcomes including technology based approaches. Finally, we briefly review treatment options for cognitive deficits, focusing on cognitive remediation programs, highlighting their effects on brain activity and conclude with the potential benefit of individualized integrated interventions combing cognitive remediation with other approaches.
精神分裂症中的认知障碍是临床和功能恢复的主要障碍之一。本专家组论文汇集了精神分裂症治疗领域的专家，讨论认知障碍领域的科学进展，以最有效的方式解决认知障碍及其后果。我们报告认知缺陷的发病和病程，将其与精神分裂症患者脑功能和结构的改变联系起来，并讨论它们在预测有风险人群向精神病转变中的作用。然后，我们参考功能和社会认知来探讨评估工具，研究主观测量方法的作用，并探讨包括基于技术的方法在内的测量功能结果的新方法。最后，我们简要回顾认知缺陷的治疗选择，重点关注认知康复计划，强调它们对大脑活动的影响，并以将认知康复与其他方法相结合的个体化综合干预的潜在益处作为结论。
