Institute of Neuroscience, Brain Research Center, school of life science, National Yang-Ming University, No. 155. Sec. 2, LiNung St., Peitou, Taipei 112, Taiwan, Republic of China.
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, No. 155-1. Sec. 2, LiNung St., Peitou, Taipei 112, Taiwan, Republic of China; Ph.D Program for the Clinical Drug Discovery from Botanical Herbs, Taipei Medical University, Taipei, Taiwan, Republic of China.
J Ethnopharmacol. 2017 Sep 14;209:50-61. doi: 10.1016/j.jep.2017.07.036. Epub 2017 Jul 22.
Metabolic syndrome and vascular dysfunction was suggested to be the risk factors for Alzheimer's disease (AD). Xuefu Zhuyu decoction (XZD) is a traditional Chinese medicine used to treat metabolic syndrome and cardiac-cerebral vascular disease. The effects of XZD on ameliorating metabolic syndrome, amyloid-related pathologies and cognitive impairment in an animal model of AD with metabolic stress was investigated.
The animal model of AD with metabolic stress was created by administrating high-fat diet and a low-dose injection of streptozotocin prior to the appearance of senile plaques in APP/PS1 transgenic mice. The diabesity-associated metabolic changes and AD-related pathological alterations were examined.
We found that XZD reduced body weight, insulin and leptin level, HOMA-IR, hepatic triglyceride, serum Aβ42 in the metabolic stressed AD animal. XZD also ameliorated oral glucose tolerant, Aβ deposition, astrocyte and microglia activation in the vicinity of plaques, and nesting behavior in the metabolic stressed AD animal.
The results of this study suggest that XZD is able to reduce the peripheral metabolic stress-mediated vascular hypoperfusion, neuroinflammation and AD-related pathology in APP/PS1 mice.
代谢综合征和血管功能障碍被认为是阿尔茨海默病（AD）的危险因素。血府逐瘀汤（XZD）是一种用于治疗代谢综合征和心脑血管疾病的中药。本研究旨在探讨 XZD 对代谢应激诱导的 AD 动物模型改善代谢综合征、淀粉样相关病理和认知障碍的作用。
通过在 APP/PS1 转基因小鼠出现老年斑之前给予高脂肪饮食和小剂量链脲佐菌素注射，建立 AD 伴代谢应激的动物模型。检测与糖尿病相关的代谢变化和与 AD 相关的病理改变。
我们发现 XZD 降低了代谢应激 AD 动物的体重、胰岛素和瘦素水平、HOMA-IR、肝甘油三酯、血清 Aβ42。XZD 还改善了代谢应激 AD 动物的口服葡萄糖耐量、Aβ 沉积、斑块附近星形胶质细胞和小胶质细胞激活以及筑巢行为。
本研究结果表明，XZD 能够减轻 APP/PS1 小鼠外周代谢应激介导的血管灌注不足、神经炎症和与 AD 相关的病理。
