Brown M J, Brown J
Lancet. 1986 Aug 23;2(8504):427-9. doi: 10.1016/s0140-6736(86)92136-7.
In the Medical Research Council trial for the treatment of mild hypertension, bendrofluazide showed an unexpected and sizeable benefit compared with propranolol in the reduction of stroke. It is suggested that this difference reflects the opposing actions of these drugs on the renin-angiotensin system. The hypothesis that angiotensin-II protects the distal smaller cerebral vessels, which are the usual site of vessel rupture in intracerebral haemorrhage, indicates that long-term benefit of angiotensin-converting-enzyme inhibitors in the treatment of hypertension cannot be assumed.
在医学研究委员会进行的治疗轻度高血压试验中，与普萘洛尔相比，苄氟噻嗪在降低中风风险方面显示出意想不到的显著益处。有人认为，这种差异反映了这些药物对肾素-血管紧张素系统的相反作用。血管紧张素-II可保护远端较小的脑血管（这是脑出血时血管破裂的常见部位）这一假说表明，不能认为血管紧张素转换酶抑制剂在高血压治疗中具有长期益处。
