Bartley P C, Hambling T E
Aust N Z J Med. 1979 Feb;9(1):49-53. doi: 10.1111/j.1445-5994.1979.tb04112.x.
HbA1 was measured by a rapid method in a routine hospital laboratory. The normal range of 5.0--8.5% compares favourably with other studies. Patients with uncontrolled diabetes had levels of HbA1 of up to 20.5% while well controlled patients had levels of HbA1 in the normal range. The level of HbA1 is relatively stable in normal subjects and does not correlate with age, sex or weight. There was a correlation (p less than 0.001) with a 1-2 hour post-prandial, post-insulin blood sugar in insulin dependent diabetics. There was a relationship between type of therapy and HbA1 level at presentation. From the study of two ketoacidotic patients, it is apparent that the level of HbA1 decreases about six weeks after the decrease in blood sugar. It is concluded that the measurement of HbA1 is a useful adjunct in the assessment of diabetic control.
在一家常规医院实验室中，采用快速方法测定糖化血红蛋白A1（HbA1）。5.0% - 8.5%的正常范围与其他研究结果相比情况良好。糖尿病控制不佳的患者HbA1水平高达20.5%，而控制良好的患者HbA1水平处于正常范围。在正常受试者中，HbA1水平相对稳定，且与年龄、性别或体重无关。在胰岛素依赖型糖尿病患者中，HbA1与餐后1 - 2小时、胰岛素注射后的血糖水平存在相关性（p小于0.001）。就诊时治疗类型与HbA1水平之间存在关联。通过对两名酮症酸中毒患者的研究发现，血糖下降后约六周，HbA1水平会降低。得出结论，HbA1的测定在评估糖尿病控制情况方面是一项有用的辅助手段。
