Paisey R B, Macfarlane D G, Sherriff R J, Hartog M, Slade R R, White D A
Diabetologia. 1980 Jul;19(1):31-4. doi: 10.1007/BF00258307.
Serial capillary blood glucose levels from insulin treated patients were recorded over 24 hour periods at fortnightly intervals for three months. Total glycosylated haemoglobin as % of HbA was measured at the end of this period by the Flückiger method, and % HbA1 by column chromatography. There were highly significant correlations between mean blood glucose levels over the three months and % HbA1 (r = 0.93, 95% confidence limits 0.84-0.98), and with total glycosylated haemoglobin (r = 0.88, 95% confidence limits 0.75-0.94). There was also a good correlation between results obtained by the two methods (r = 0.81, p less than 0.0001). There were less strong correlations between % HbA1 and blood glucose levels during each of the three months before the estimation, with percentage of glucose levels greater than 10 mmol/l and with mean fasting blood glucose. These data support the hypothesis that % HbA1 and total glycosylated haemoglobin are satisfactory measurements of short term diabetic control.
对接受胰岛素治疗患者的毛细血管血糖水平进行连续记录，每两周记录一次24小时期间的血糖水平，持续三个月。在此期间结束时，采用弗吕基格法测定糖化血红蛋白占HbA的百分比，通过柱色谱法测定HbA1的百分比。三个月的平均血糖水平与HbA1百分比（r = 0.93，95%置信区间0.84 - 0.98）以及与总糖化血红蛋白（r = 0.88，95%置信区间0.75 - 0.94）之间存在高度显著的相关性。两种方法所得结果之间也具有良好的相关性（r = 0.81，p小于0.0001）。在估计前的三个月中，每个月的HbA1百分比与血糖水平、血糖水平大于10 mmol/l的百分比以及平均空腹血糖之间的相关性较弱。这些数据支持了以下假设，即HbA1百分比和总糖化血红蛋白是短期糖尿病控制的满意指标。
