Louilot A, Le Moal M, Simon H
Life Sci. 1986 Aug 25;39(8):685-92. doi: 10.1016/0024-3205(86)90015-9.
The effects of buspirone, a buspirone analogue (BMY 13805) and a buspirone metabolite (1-PP) on dopaminergic metabolism in the nucleus accumbens were investigated using in vivo voltammetry. Differential pulse voltammetry coupled with electrochemically pretreated carbon fiber electrodes was used to provide a continuous and selective measure of the 3,4-dihydroxyphenylacetic acid (DOPAC). An implanted micromanipulator enabled the use of freely moving animals. Buspirone injections induced a marked and rapid increase of the DOPAC peak in the nucleus accumbens. Buspirone was 10 times more potent when injected subcutaneously than intraperitoneally. BMY 13805 and 1-PP were without effect on dopaminergic metabolism in the nucleus accumbens. In conclusion, the anxiolytic properties of these drugs and their effects on dopaminergic metabolism do not appear related.
使用体内伏安法研究了丁螺环酮、一种丁螺环酮类似物（BMY 13805）和一种丁螺环酮代谢物（1-PP）对伏隔核中多巴胺能代谢的影响。采用差分脉冲伏安法结合电化学预处理的碳纤维电极，以连续、选择性地测量3,4-二羟基苯乙酸（DOPAC）。植入式微操纵器使得能够对自由活动的动物进行实验。注射丁螺环酮可使伏隔核中的DOPAC峰值显著且迅速升高。丁螺环酮皮下注射时的效力比腹腔注射时强10倍。BMY 13805和1-PP对伏隔核中的多巴胺能代谢没有影响。总之，这些药物的抗焦虑特性与其对多巴胺能代谢的影响似乎并无关联。
