Gonzalez-Mora J L, Guadalupe T, Mas M
Department of Physiology, University of La Laguna, Tenerife, Spain.
Brain Res Bull. 1990 Nov;25(5):729-33. doi: 10.1016/0361-9230(90)90050-a.
The effects of an acute subcutaneous injection of ovine prolactin (PRL) or its vehicle on total motor activity and the extracellular levels of dopamine (DA), DOPAC and ascorbic acid (AA) in the nucleus accumbens were monitored simultaneously in freely behaving male rats. The neurochemical data were obtained by Differential Normal Pulse Voltammetry using electrochemically pretreated carbon fiber microelectrodes and numerical waveform analysis of the catechol peak. PRL treatment increased the extracellular levels of DA and DOPAC in the nucleus accumbens, which is consistent with previous reports using other methodologies. Furthermore, there was a concomitant decrease in the AA signals and motor activity. These findings suggest an antagonistic action of PRL on dopaminergic transmission in the mesolimbic system.
在自由活动的雄性大鼠中，同时监测急性皮下注射绵羊催乳素（PRL）或其赋形剂对总运动活性以及伏隔核中多巴胺（DA）、3,4-二羟基苯乙酸（DOPAC）和抗坏血酸（AA）细胞外水平的影响。神经化学数据通过使用经电化学预处理的碳纤维微电极的差分正常脉冲伏安法以及儿茶酚峰的数值波形分析获得。PRL处理增加了伏隔核中DA和DOPAC的细胞外水平，这与先前使用其他方法的报告一致。此外，AA信号和运动活性同时降低。这些发现表明PRL对中脑边缘系统多巴胺能传递具有拮抗作用。
