Louilot A, Le Moal M, Simon H
Brain Res. 1986 Nov 12;397(2):395-400. doi: 10.1016/0006-8993(86)90646-3.
The reactivity of dopaminergic (DA) terminals in the nucleus accumbens was investigated in male rats submitted to tail-pinch or various social interactions. The DA activity was assessed by measurement of the presynaptic metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) by using differential pulse voltammetry in free moving preparations. Tail-pinch lasting 5 min or 10 min was followed by increases in DA activity of 25% and 35%, respectively. Three types of social interaction were used: interaction with an aggressive male congener, interaction with a non-aggressive male congener or interaction with a female congener. The greatest increase in dopaminergic activity (40%) was observed after the aggressive interaction. The reactivity of the DA neurons within the nucleus accumbens is, therefore, dependent on the characteristics of the behavioral situation.
在接受尾部夹捏或各种社交互动的雄性大鼠中，研究了伏隔核中多巴胺能（DA）终末的反应性。通过在自由活动的动物制剂中使用差分脉冲伏安法测量突触前代谢物3,4 - 二羟基苯乙酸（DOPAC）来评估DA活性。持续5分钟或10分钟的尾部夹捏分别使DA活性增加25%和35%。使用了三种类型的社交互动：与具有攻击性的雄性同类动物互动、与无攻击性的雄性同类动物互动或与雌性同类动物互动。在攻击性互动后观察到多巴胺能活性的最大增加（40%）。因此，伏隔核内DA神经元的反应性取决于行为情境的特征。
