Pfützner Andreas, Demircik Filiz, Sachsenheimer Daniela, Spatz Jan, Pfützner Anke H, Ramljak Sanja
1 Pfützner Science & Health Institute, Mainz, Germany.
2 Sciema UG, Mainz, Germany.
J Diabetes Sci Technol. 2017 May;11(3):577-583. doi: 10.1177/1932296816678428. Epub 2016 Nov 15.
The pentose xylose is enriched in edible algae, and is increasingly used as a slowly metabolized carbohydrate in functional food. It is known to interfere with glucose-dehydrogenase-based (GDH) blood glucose measurement systems for patients self-testing. The aim of our study was to investigate the extent of xylose interference in commercially available blood glucose meters. A heparinized whole blood sample was manipulated to contain 3 different glucose concentrations (50-80 mg/dL, 130-160 mg/dL, and 250-300 mg/dL) and 4 different xylose concentrations (0 mg/dL, 25 mg/dL, 50 mg/dL, and 100 mg/dL). Each sample was measured 3 times with 2 different strip lots per test meter (AccuChek Aviva, AccuChek Connect, Contour Next, FreeStyle Freedom Lite, FreeStyle Insulinx, MyStar Extra, OneTouch Verio IQ, and Wellion Calla, reference: YSI GlucoStat analyzer). For analysis, we calculated the xylose capture rate, that is, the xylose amount wrongly displayed as glucose. No xylose interference was seen with 4 meters: AccuChek Aviva (mean capture rate 0%), AccuChek Connect (-2%), MyStar Extra (10%), and Wellion Calla (8%). In contrast, substantial interference was observed with Contour Next (100%), FreeStyle Freedom Lite (104%), FreeStyle Insulinx (120%), and OneTouch Verio IQ (162%). We observed xylose interference in several GDH-based meters. This may become important with increased use of xylose in dietary and functional food products, in particular in products designed for weight loss. Our findings may affect the meter selection for patients who are consuming such food products as part of their lifestyle treatment regimen.
戊糖木糖在可食用藻类中含量丰富，并且越来越多地被用作功能性食品中一种代谢缓慢的碳水化合物。已知它会干扰基于葡萄糖脱氢酶（GDH）的血糖仪自我检测系统，用于患者自测血糖。我们研究的目的是调查木糖对市售血糖仪的干扰程度。将一份肝素化全血样本处理成含有3种不同葡萄糖浓度（50 - 80mg/dL、130 - 160mg/dL和250 - 300mg/dL）以及4种不同木糖浓度（0mg/dL、25mg/dL、50mg/dL和100mg/dL）的样本。每个样本使用每台血糖仪的2个不同试纸批次进行3次测量（罗氏卓越型血糖仪、罗氏整合型血糖仪、拜安时Next血糖仪、稳豪倍易血糖仪、稳豪倍优型胰岛素笔用血糖仪、美奇血糖仪、稳悦智佳血糖仪和惠灵凯立血糖仪，对照：YSI葡萄糖分析仪）。为了进行分析，我们计算了木糖捕获率，即被错误显示为葡萄糖的木糖量。有4款血糖仪未观察到木糖干扰：罗氏卓越型血糖仪（平均捕获率0%）、罗氏整合型血糖仪（-2%）、美奇血糖仪（10%）和惠灵凯立血糖仪（8%）。相比之下，拜安时Next血糖仪（100%）、稳豪倍易血糖仪（104%）、稳豪倍优型胰岛素笔用血糖仪（120%）和稳悦智佳血糖仪（162%）观察到显著干扰。我们在几种基于GDH的血糖仪中观察到木糖干扰。随着木糖在饮食和功能性食品中的使用增加，尤其是在为减肥设计的产品中，这可能变得很重要。我们的研究结果可能会影响那些将此类食品作为生活方式治疗方案一部分的患者对血糖仪的选择。
