Schechter M D
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Pharmacol Biochem Behav. 1988 Sep;31(1):239-42. doi: 10.1016/0091-3057(88)90340-1.
In an effort to reduce the often extensive period of time needed to train rats to discriminate between a drugged and nondrugged state, a fast training regimen was employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the training drug in ten rats. This protocol consisted of one to three training sessions per day and it was compared to the more conventional method of once-per-day training in an equal number of rats. Results indicate that the fast-trained rats learned the discrimination in significantly fewer sessions than the slowly-trained rats. However, the subsequent dose-response experiments indicate that when the fast-trained rats are tested with various doses of MDMA, without prior vehicle treatment, their sensitivity to the drug is less than that of the slowly-trained rats. When a vehicle session is presented prior to drug dose-response testing, both groups perform similarly. It appears that the preceding vehicle sessions function as a reference point for the fast-trained rats and, although the more rapid training regimen allows for faster learning, these treatment regimens should be employed with caution when subsequent dose-response tests and generalization tests with other drugs are conducted.
为了减少训练大鼠区分用药状态和未用药状态通常所需的较长时间，对10只大鼠采用了快速训练方案，使用1.5毫克/千克3,4-亚甲基二氧基甲基苯丙胺（摇头丸）作为训练药物。该方案包括每天进行一至三次训练，并与在相同数量大鼠中采用的更传统的每日一次训练方法进行比较。结果表明，快速训练的大鼠比缓慢训练的大鼠在显著更少的训练次数中学会了辨别。然而，随后的剂量反应实验表明，当快速训练的大鼠在未事先进行溶剂处理的情况下用不同剂量的摇头丸进行测试时，它们对药物的敏感性低于缓慢训练的大鼠。当在药物剂量反应测试之前进行一次溶剂处理时，两组的表现相似。似乎先前的溶剂处理对快速训练的大鼠起到了参考点的作用，并且尽管更快速的训练方案能够实现更快的学习，但在随后进行与其他药物的剂量反应测试和泛化测试时，应谨慎采用这些处理方案。
