Martin-Iverson M T, Radke J M, Vincent S R
Pharmacol Biochem Behav. 1986 Jun;24(6):1707-14. doi: 10.1016/0091-3057(86)90509-5.
The effects of prior treatment with cysteamine, a drug which appears to deplete selectively the neuropeptide somatostatin, on apomorphine-induced stereotypy and amphetamine-induced locomotor activity and conditioned place preferences were investigated. Twelve hours following systemic cysteamine injections apomorphine-induced stereotypy was attenuated and striatal somatostatin levels were reduced by half. Systemic cysteamine also decreased the motor stimulant effects of amphetamine, without influencing the rewarding properties as determined by the conditioned place preference procedure. Direct injections of cysteamine into the nucleus accumbens also decreased the locomotor response to amphetamine, and produced a local reduction in somatostatin levels in the accumbens. Cysteamine did not appear to alter monoamine turnover in the striatum after either systemic or intra-accumbens injections. These results suggest that somatostatin in the nucleus accumbens and caudate-putamen modulates the motor, but not the reinforcing properties of dopaminergic drugs, possibly via an action postsynaptic to dopamine-releasing terminals. Furthermore, it is evident from these results that cysteamine is an important tool with which to study the central actions of somatostatin.
研究了半胱胺（一种似乎能选择性耗尽神经肽生长抑素的药物）先前治疗对阿扑吗啡诱导的刻板行为、苯丙胺诱导的运动活性和条件性位置偏爱效应的影响。全身注射半胱胺12小时后，阿扑吗啡诱导的刻板行为减弱，纹状体生长抑素水平降低一半。全身注射半胱胺也降低了苯丙胺的运动兴奋作用，但不影响条件性位置偏爱程序所确定的奖赏特性。直接向伏隔核注射半胱胺也降低了对苯丙胺的运动反应，并使伏隔核内的生长抑素水平局部降低。全身或伏隔核内注射半胱胺后，半胱胺似乎并未改变纹状体内的单胺周转率。这些结果表明，伏隔核和尾状核-壳核中的生长抑素可能通过对多巴胺释放终末的突触后作用来调节多巴胺能药物的运动作用，但不调节其奖赏特性。此外，从这些结果可以明显看出，半胱胺是研究生长抑素中枢作用的重要工具。
