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离子液体在改善酶法有机合成中的应用。

Ionic Liquids as Tool to Improve Enzymatic Organic Synthesis.

机构信息

Department of Chemistry and Biotechnology, Graduate School of Engineering and ‡Center for Research on Green Sustainable Chemistry, Tottori University , 4-101 Koyama-minami, Tottori 680-8552, Japan.

出版信息

Chem Rev. 2017 Aug 9;117(15):10567-10607. doi: 10.1021/acs.chemrev.7b00158. Epub 2017 Jul 26.

Abstract

Ionic liquids (ILs) have now been acknowledged as reaction media for biotransformations. The first three examples were reported in this field in 2000, and since then, numerous applications have been reported for biocatalytic reactions using ILs. Two topics using ILs for enzymatic reactions have been reviewed from the standpoint of biocatalyst mediating organic synthesis; the first is "Biocatalysis in Ionic Liquids" which includes various types of biocatalytic reactions in ILs (section 2): (1) recent examples of lipase-mediated reactions using ILs as reaction media for biodiesel oil production and for sugar ester production, (2) oxidase-catalyzed reactions in ILs, (3) laccase-catalyzed reactions, (4) peroxidase-catalyzed reactions, (4) cytochrome-mediated reactions, (5) microbe-mediated hydrations, (6) protease-catalyzed reactions, (8) whole cell mediated asymmetric reduction of ketones, (10) acylase-catalyzed reactions, (11) glycosylation or cellulase-mediated hydrolysis of polysaccharides, (12) hydroxynitrile lyase-catalyzed reaction, (13) fluorinase or haloalkane dehydrogenase-catalyzed reaction, (14) luciferase-catalyzed reactions, and (15) biocatalytic promiscuity of enzymatic reactions for organic synthesis using ILs. The second is "Enzymes Activated by Ionic Liquids for Organic Synthesis", particularly describing the finding story of activation of lipases by the coating with a PEG-substituted IL (section 3). The author's opinion toward "Future Perspectives of Using ILs for Enzymatic Reactions" has also been discussed in section 4.

摘要

离子液体(ILs)现已被公认为生物转化的反应介质。该领域于 2000 年首次报道了前三个例子,此后,使用 ILs 进行生物催化反应的应用已被广泛报道。从有机合成中生物催化剂介导的角度综述了两个使用 ILs 进行酶反应的主题;第一个是“离子液体中的生物催化”,其中包括 ILs 中各种类型的生物催化反应(第 2 节):(1)使用 IL 作为生物柴油油生产和糖酯生产的反应介质的脂肪酶介导反应的最新示例,(2)IL 中的氧化酶催化反应,(3)漆酶催化反应,(4)过氧化物酶催化反应,(4)细胞色素介导的反应,(5)微生物介导的水合作用,(6)蛋白酶催化反应,(8)全细胞介导的酮不对称还原,(10)酰基酶催化反应,(11)糖基化或纤维素酶介导的多糖水解,(12)羟腈裂解酶催化反应,(13)氟酶或卤代烷脱氢酶催化反应,(14)荧光素酶催化反应,以及(15)使用 ILs 进行有机合成的酶反应的生物催化混杂性。第二个是“离子液体激活的用于有机合成的酶”,特别是在第 3 节中描述了通过用 PEG 取代的 IL 涂层激活脂肪酶的发现故事。作者还在第 4 节中讨论了“未来使用 ILs 进行酶反应的观点”。

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