de Morais Damila Rodrigues, Barbosa Ingrid Lopes, Cunha Kelly Francisco, Tripodi Guilherme Lucas, Angolini Célio Fernando Figueiredo, Franco Marcos Fernando, de Aquino Elvis Medeiros, Eberlin Marcos Nogueira, Costa Jose Luiz
ThoMSon Mass Spectrometry Laboratory, University of Campinas, Institute of Chemistry, Campinas, São Paulo, 13083-970, Brazil.
Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, 13083-859, Brazil.
J Mass Spectrom. 2017 Oct;52(10):701-706. doi: 10.1002/jms.3977.
The increasing number of new psychoactive substances (NPS) and their quick worldwide spreading, often only slightly modified in the form of new derivatives and analogues, have brought the need for fast, wide-ranging, and unequivocal identification methods in clinical and forensic investigations. Because it usually provides secure results, gas chromatography coupled to mass spectrometry (GC-MS) has been routinely employed as the standard technique for the detection of NPS in blotter papers. For 25I-NBOH (N-(2-hydroxybenzyl)-2-(4-iodo-2,5-dimethoxyphenyl)ethan-1-aminium), however, GC-MS analysis of an blotter paper extract leads to incorrect results. In this work, we investigated whether easy ambient sonic-spray mass spectrometry imaging (EASI-IMS), and ambient ionization MS method can be applied directly to the surface of the sample requiring therefore no extraction or sample preparations, would serve as an efficient, sensitive, and secure alternative for 25I-NBOH screening.
新型精神活性物质（NPS）数量不断增加，且在全球迅速传播，其往往仅以新衍生物和类似物的形式稍有改动，这使得临床和法医调查中需要快速、广泛且明确的识别方法。由于气相色谱-质谱联用（GC-MS）通常能提供可靠结果，它已被常规用作检测吸墨纸上NPS的标准技术。然而，对于25I-NBOH（N-(2-羟基苄基)-2-(4-碘-2,5-二甲氧基苯基)乙铵），对吸墨纸提取物进行GC-MS分析会得出错误结果。在这项工作中，我们研究了简便常压超声喷雾质谱成像（EASI-IMS），一种无需萃取或样品制备、可直接应用于样品表面的常压电离质谱方法，是否能作为25I-NBOH筛查的高效、灵敏且可靠的替代方法。
