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Quantitative determination of chloroquine and desethylchloroquine in biological fluids by high performance thin layer chromatography.

作者信息

Betschart B, Steiger S

出版信息

Acta Trop. 1986 Jun;43(2):125-30.

PMID:2874709
Abstract

A high performance thin layer chromatographic (HPTLC) method for chloroquine (CQ) and desethylchloroquine (DCQ) determinations in plasma, erythrocytes and urine is described. Samples extracted by heptane from an alkaline water phase are separated on HPTLC silica gel plates, using toluene/diethylamine (9:1). The compounds are quantified by scanning fluorescent signals. The detection limit is 0.01 mumol/1 for CQ and DCQ, with an extraction efficiency of 76 +/- 7%. Further simplification could make the method suitable for use in field surveys.

摘要

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引用本文的文献

1
Colorimetric and thin-layer chromatographic methods for field assay of chloroquine and its metabolites in urine.用于尿液中氯喹及其代谢物现场检测的比色法和薄层色谱法。
Bull World Health Organ. 1987;65(5):615-23.