Ramirez Maria Erika G, Bargman Joanne M
University Health Network, 200 Elizabeth Street 8N-840, Toronto M5G 2C4, Canada.
J Adv Res. 2017 Sep;8(5):551-554. doi: 10.1016/j.jare.2017.04.006. Epub 2017 May 2.
Asymptomatic hyperuricemia is increasing in prevalence. There is a growing body of literature suggesting that uric acid has deleterious effects on vascular health and renal histological integrity. Several trials, reviewed herein, suggest that lowering the serum uric acid level is associated with a slowing in the rate of renal deterioration in those with chronic kidney disease. Given that there is little available in the general armamentarium to slow the rate of kidney deterioration, strong consideration could be given to the administration of agents or lifestyle changes that decrease uric acid production in hyperuricemic patients with deteriorating kidney function.
无症状性高尿酸血症的患病率正在上升。越来越多的文献表明，尿酸对血管健康和肾脏组织学完整性具有有害影响。本文综述的几项试验表明，降低血清尿酸水平与减缓慢性肾脏病患者的肾脏恶化速度相关。鉴于在常规治疗手段中几乎没有什么可以减缓肾脏恶化速度，对于肾功能恶化的高尿酸血症患者，可大力考虑给予能减少尿酸生成的药物或改变生活方式。
