Elsholz Alexander K W, Birk Marlene S, Charpentier Emmanuelle, Turgay Kürşad
Department of Regulation in Infection Biology, Max Planck Institute for Infection BiologyBerlin, Germany.
The Laboratory for Molecular Infection Sweden, Department of Molecular Biology, Umeå Centre for Microbial Research, Umeå UniversityUmeå, Sweden.
Front Mol Biosci. 2017 Jul 12;4:44. doi: 10.3389/fmolb.2017.00044. eCollection 2017.
Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism . We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics.
在此，我们综述了AAA+蛋白酶复合体在革兰氏阳性模式生物的蛋白质稳态、应激反应控制以及细胞发育途径中的多种作用和功能，这些作用和功能是通过调节性和一般性蛋白水解实现的。我们详细讨论了AAA+蛋白复合体在控制芽孢形成、热休克反应以及衔接蛋白在这些过程中的作用方面的复杂参与情况。对这些蛋白复合体及其衔接蛋白的研究揭示了它们与革兰氏阳性病原体的相关性以及作为新型抗生素靶点的潜力。
