Abila B, Wilson J F, Marshall R W, Richens A
Br J Clin Pharmacol. 1986 Jul;22(1):104-7.
The effects of intravenous doses of propranolol, sotalol, timolol, atenolol and placebo on exercise-induced tachycardia and exercise-induced increases in hand tremor were assessed in four healthy volunteers. All active drugs produced significant reductions in exercise-induced tachycardia. Exercise caused consistent significant increases in hand tremor which were blocked by the three non-cardioselective drugs but not by atenolol or placebo. The blockade of exercise-induced hand tremor is suggested as a possible test for the assessment of the selectivity of beta-adrenoceptor blockade in man.
在四名健康志愿者中评估了静脉注射普萘洛尔、索他洛尔、噻吗洛尔、阿替洛尔和安慰剂对运动诱发的心动过速以及运动诱发的手部震颤增加的影响。所有活性药物均使运动诱发的心动过速显著降低。运动导致手部震颤持续显著增加，三种非心脏选择性药物可阻断这种增加，但阿替洛尔或安慰剂则不能。运动诱发的手部震颤的阻断被认为是评估人体β-肾上腺素能受体阻断选择性的一种可能测试。
