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拟交感神经药引起的震颤由β2-肾上腺素能受体介导。

Tremor caused by sympathomimetics is mediated by beta2-adrenoreceptors.

作者信息

Larsson S, Svedmyr N

出版信息

Scand J Respir Dis. 1977;58(1):5-10.

PMID:190674
Abstract

Tremor caused by beta-adrenostimulating drugs is known to be mediated by beta-receptors in skeletal muscles. In this study it was shown that tremor caused by terbutaline could be blocked by propranolol, a drug with both beta1- and beta2-blocking properties, but not by metoprolol, a beta1-selective antagonist. It is concluded that tremor caused by sympathomimetics in man is mainly mediated by beta2-receptors.

摘要

已知由β-肾上腺素能刺激药物引起的震颤是由骨骼肌中的β受体介导的。在本研究中表明，特布他林引起的震颤可被普萘洛尔（一种具有β1和β2阻断特性的药物）阻断，但不能被美托洛尔（一种β1选择性拮抗剂）阻断。由此得出结论，人类拟交感神经药引起的震颤主要由β2受体介导。

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