Porokeratosis

Porokeratosis is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. The distinct histologic hallmark of porokeratosis is cornoid lamella, a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including: Disseminated superficial actinic porokeratosis. Classical porokeratosis of Mibelli. Porokeratosis plantaris, palmaris, et disseminate. Linear porokeratosis  . Additionally, rare variants include: Genitogluteal porokeratosis. Facial porokeratosis. Giant porokeratosis. Porokeratosis ptychotropica. Hypertrophic verrucous porokeratosis. Eruptive pruritic papular porokeratosis. Follicular porokeratosis . Reticulate porokeratosis  . Variants can occur together but rarely do. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best conducted with a biopsy of the elevated border. Although multiple therapies exist for porokeratosis (including topical, systemic, and surgical), there are no standard guidelines for treatment.