Abouelfad Dalia M, Yassen Noha N, Amin Hebat Allah A, Shabana Marwa E
Pathology Department, Medical Division, National Research Centre, Cairo, Egypt. Email:
Asian Pac J Cancer Prev. 2017 Jul 27;18(7):1737-1741. doi: 10.22034/APJCP.2017.18.7.1737.
Lymphoepithelioma-like carcinoma (LELC) of the breast is an exceedingly rare variant of mammary cancer. To our knowledge, only twenty - one cases have been reported in the literature. Diagnosis of this type of mammary carcinoma may be challenging, owing to its rarity and the histopathological similarity to common inflammatory and malignant lesions of the breast mainly granulomatous mastitis, medullary carcinoma, pleomorphic lobular carcinoma, lymphoma and other hematological malignancies. Our case is the 22nd case of lymphoepithelioma-like carcinoma reported in the breast, presenting with a palpable tender mass in a post-menopausal female. Her clinical picture had been mistaken for inflammatory disease. We present our case, with its detailed clinical history, radiological findings, histopathological and immune-histochemical findings along with a review of the literature. Highlighting this type of tumors may help in appropriate diagnosis. Moreover, studying the behavior of these rare neoplasms is essential to expedite treatment for this tumor type.
乳腺淋巴上皮瘤样癌(LELC)是一种极其罕见的乳腺癌变体。据我们所知,文献中仅报道了21例。由于其罕见性以及与乳腺常见炎症和恶性病变(主要是肉芽肿性乳腺炎、髓样癌、多形性小叶癌、淋巴瘤和其他血液系统恶性肿瘤)在组织病理学上的相似性,这种类型的乳腺癌诊断可能具有挑战性。我们的病例是乳腺中报道的第22例淋巴上皮瘤样癌,发生在一名绝经后女性身上,表现为可触及的压痛肿块。她的临床表现曾被误诊为炎症性疾病。我们展示我们的病例,包括详细的临床病史、放射学检查结果、组织病理学和免疫组织化学检查结果,并对文献进行综述。强调这类肿瘤可能有助于进行恰当诊断。此外,研究这些罕见肿瘤的行为对于加快针对这种肿瘤类型的治疗至关重要。