Salehiazar Sara, Huang Hehua, Aghighi Maryam, Venegas Rose
Pathology and Laboratory Medicine, Harbor-UCLA (University of California Los Angeles) Medical Center, Torrance, USA.
Pathology, Harbor-UCLA (University of California Los Angeles) Medical Center, Torrance, USA.
Cureus. 2022 Sep 16;14(9):e29231. doi: 10.7759/cureus.29231. eCollection 2022 Sep.
Lymphoepithelioma carcinoma (LELC) is an extremely rare type of mammary cancer. Based on the histology, it can be misdiagnosed with inflammatory lesions like mastitis and medullary carcinoma or other hematopoietic neoplasms like lymphoma in the breast. Since LELC has a good response to chemotherapy with a good prognosis, t is prognostically important to recognize LELC. We report a rare case of LELC in a 51-year-old pre-menopausal female with a left breast mass, diagnosed with invasive ductal carcinoma (IDC), LELC type, treated with mastectomy, followed by adjuvant chemotherapy and radiotherapy, with a disease-free interval of 10 months. Herein, we present the case with its clinical presentation, radiologic imaging, histopathological features, and immunohistochemistry (IHC) findings. The rarity of this type of breast tumor warrants studying the behavior of these uncommon tumors to avoid misdiagnosis and establish well-defined criteria for diagnosis.
淋巴上皮瘤样癌(LELC)是一种极为罕见的乳腺癌类型。基于组织学特征,它可能被误诊为诸如乳腺炎和髓样癌等炎症性病变,或乳腺中的其他造血系统肿瘤如淋巴瘤。由于LELC对化疗反应良好且预后较好,因此识别LELC在预后方面具有重要意义。我们报告了一例罕见的LELC病例,患者为一名51岁的绝经前女性,左乳有肿块,最初诊断为浸润性导管癌(IDC),LELC型,接受了乳房切除术,随后进行辅助化疗和放疗,无病生存期为10个月。在此,我们展示该病例的临床表现、放射影像学、组织病理学特征及免疫组化(IHC)结果。这种类型的乳腺肿瘤较为罕见,有必要研究这些不常见肿瘤的行为,以避免误诊并建立明确的诊断标准。