镍催化唑与芳香腈的偶联反应。
Nickel-Catalyzed Coupling of Azoles with Aromatic Nitriles.
机构信息
Department of Chemistry, St. Olaf College , 1520 St. Olaf Avenue, Northfield, Minnesota 55057, United States.
出版信息
Org Lett. 2017 Aug 18;19(16):4271-4274. doi: 10.1021/acs.orglett.7b01938. Epub 2017 Jul 27.
Abstract
This manuscript describes the Ni-catalyzed coupling of azoles with aromatic nitriles. The use of BPh promotes these arylations with electronically diverse azoles and benzonitriles. While the nickel catalyst is necessary for the arylations of phenyl oxazoles, arylation of benzoxazoles with some nitriles affords the arylated products even in the absence of the Ni catalyst albeit in lower yield than the catalyzed process. The Ni-catalyzed process exhibits higher rates and a broader scope than the uncatalyzed transformation.
摘要
这篇手稿描述了镍催化的唑与芳香腈的偶联反应。BPh 的使用促进了具有不同电子性质的唑和苯甲腈的芳基化反应。虽然镍催化剂对于苯基恶唑的芳基化反应是必需的，但在没有 Ni 催化剂的情况下，一些腈的苯并恶唑的芳基化反应仍然可以得到芳基化产物，尽管收率低于催化过程。与未催化的转化相比，Ni 催化过程表现出更高的速率和更广泛的范围。
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