Shanghai High School, 400 Shangzhong Road, Shanghai 200231, China.
Shanghai Research Center for Model Organisms, Pudong, Shanghai 201203, China; School of Life Science and Technology, Tongji University, 1239 Siping Road, Shanghai 200092, China.
Exp Gerontol. 2017 Oct 15;97:89-96. doi: 10.1016/j.exger.2017.07.015. Epub 2017 Jul 25.
Tea includes puer tea, black tea, green tea and many others. By using model organism Caenorhabditis elegans, the anti-aging and anti-oxidation effects of tea water extract were systemically examined in this study. We found that water extract of puer tea, black tea and green tea all increased the lifespan of worms, postponed Aβ-induced progressive paralysis in Alzheimer's disease transgenic worms, and improved the tolerance of worms to the oxidative stress induced by heavy metal Cr. Moreover, the anti-oxidation effects of tea water extract at low concentration were different among 4 kinds of brands of green tea. The underlying mechanisms were further explored using genetically manipulated-mutant worms. The anti-oxidative stress effects of green tea water extract depend on the dietary restriction and germline signaling pathways, but not the FOXO and mitochondrial respiratory chain signals. Therefore, tea water extract provides benefits of anti-aging, anti-AD and anti-oxidation.
茶包括普洱茶、红茶、绿茶等。本研究通过使用模式生物秀丽隐杆线虫，系统地研究了茶水提取物的抗衰老和抗氧化作用。我们发现，普洱茶、红茶和绿茶的水提取物都能延长线虫的寿命，延缓阿尔茨海默病转基因线虫中 Aβ诱导的进行性瘫痪，并提高线虫对重金属 Cr 诱导的氧化应激的耐受性。此外，4 种品牌的绿茶的水提取物的低浓度抗氧化作用不同。进一步使用遗传操作的突变型线虫探索了其潜在机制。绿茶水提取物的抗氧化应激作用取决于饮食限制和生殖细胞信号通路，而不是 FOXO 和线粒体呼吸链信号。因此，茶水提取物具有抗衰老、抗 AD 和抗氧化作用。
