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电针治疗重症急性胰腺炎所致肺损伤患者的临床疗效

Clinical Effect of Electroacupuncture on Lung Injury Patients Caused by Severe Acute Pancreatitis.

作者信息

Li Li, Yu Jianbo, Mu Rui, Dong Shuan

机构信息

Department of Anesthesiology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China.

Department of Anesthesiology, Tianjin Nankai Hospital, Tianjin 300100, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:3162851. doi: 10.1155/2017/3162851. Epub 2017 Jun 29.

Abstract

This study aimed to investigate the effects of electroacupuncture at the Lieque, Chize, and Zusanli points in patients with lung injury caused by severe acute pancreatitis. Patients with acute respiratory distress syndrome (ARDS) induced by severe acute pancreatitis (SAP) were randomly divided into three groups based on the treatment: conventional therapy alone (group A), electroacupuncture of nonacupoints with conventional therapy (group B), and electroacupuncture at the Lieque (LU7), Chize (LU5), and Zusanli (ST36) points (group C) once a day for 5 days. Arterial blood samples were obtained for blood gas analysis before electroacupuncture (1) and 3 (2) and 5 (3) days after electroacupuncture. The oxygenation index was significantly higher in all groups at 2 and 3 than that at 1, while the APACHE-II scores were decreased significantly. The expression of TNF- was significantly decreased and the IL-10 was significantly increased in all groups at 3. The oxygenation index at 2 and 3 was significantly higher in group C than that in group B. Electroacupuncture at Lieque, Chize, and Zusanli can lessen the lung injury induced by SAP, and the mechanism may be related to the decreased TNF- and increased IL-10 value. Clinical Registration Number is ChiCTR-ICR-15006850.

摘要

本研究旨在探讨针刺列缺、尺泽、足三里穴对重症急性胰腺炎所致肺损伤患者的影响。将重症急性胰腺炎(SAP)诱发的急性呼吸窘迫综合征(ARDS)患者按治疗方法随机分为三组:单纯常规治疗组(A组)、常规治疗加非穴位电针组(B组)、列缺(LU7)、尺泽(LU5)、足三里(ST36)穴电针组(C组),每日1次,共5天。在电针前(1)、电针后3天(2)和5天(3)采集动脉血样本进行血气分析。所有组在电针后2天和3天的氧合指数均显著高于电针前1天,而急性生理与慢性健康状况评分系统(APACHE-II)评分显著降低。所有组在电针后3天肿瘤坏死因子(TNF-)表达显著降低,白细胞介素-10(IL-10)显著升高。C组在电针后2天和3天的氧合指数显著高于B组。针刺列缺、尺泽、足三里可减轻SAP所致的肺损伤,其机制可能与TNF-降低和IL-10升高有关。临床注册号为ChiCTR-ICR-15006850。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09ea/5511651/66ae56124042/ECAM2017-3162851.001.jpg

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