Sahin Abdurrahman, Cihangiroglu Gulcin, Bilgic Yilmaz, Calhan Turan, Cengiz Mustafa
Department of Gastroenterology, Elazig Training and Research Hospital, Elazig, Turkey.
Department of Pathology, Elazig Training and Research Hospital, Elazig, Turkey.
North Clin Istanb. 2017 May 10;4(1):13-21. doi: 10.14744/nci.2017.85520. eCollection 2017.
The primary reason for obtaining duodenal biopsy sample is to diagnose celiac disease. () and drug injury are common causes of duodenitis. The aim of this retrospective study was to explore effects of and drugs on duodenal mucosa.
Duodenal biopsy samples of patients who underwent upper gastrointestinal endoscopy (UGIE) between February 2014 and December 2014 were retrospectively examined. Clinical symptoms, referral indications, endoscopic findings, status, and drug history were recorded. Duodenal biopsy findings were compared based on presence of and drug history.
Of 2389 patients who underwent UGIE, 206 had duodenal biopsy. Eight patients (3.9%) were diagnosed with celiac disease. After excluding cases with celiac disease, 76 patients of remaining 198 patients (36.9%) had duodenal histopathological abnormality. was found in 95 (47.9%) patients. Drug usage was less common (42%). Of patients who had histopathological duodenitis, 59% were -infected. Rate of duodenitis was higher in (+) group than in (-) group (45% vs 27.1%; odds ratio, 2.4; 95% confidence interval, 1.3-4.4; p=0.005). There was no difference between groups regarding drug use in terms of histopathological duodenitis.
is the major contributor to duodenitis in high prevalence regions. Serological testing may be more appropriate before performing duodenal biopsy in patients with suspected celiac disease.
获取十二指肠活检样本的主要原因是诊断乳糜泻。（）和药物损伤是十二指肠炎症的常见病因。本回顾性研究的目的是探讨（）和药物对十二指肠黏膜的影响。
对2014年2月至2014年12月期间接受上消化道内镜检查（UGIE）的患者的十二指肠活检样本进行回顾性检查。记录临床症状、转诊指征、内镜检查结果、（）状态和用药史。根据（）和用药史比较十二指肠活检结果。
在2389例接受UGIE的患者中，206例进行了十二指肠活检。8例（3.9%）被诊断为乳糜泻。排除乳糜泻病例后，其余198例患者中有76例（36.9%）存在十二指肠组织病理学异常。95例（47.9%）患者检测到（）。药物使用情况较少见（42%）。在有组织病理学十二指肠炎症的患者中，59%感染了（）。（）阳性组的十二指肠炎症发生率高于（）阴性组（45%对27.1%；优势比，2.4；95%置信区间，1.3 - 4.4；p = 0.005）。在组织病理学十二指肠炎症方面，两组在药物使用方面无差异。
在高流行地区，（）是十二指肠炎症的主要促成因素。对于疑似乳糜泻的患者，在进行十二指肠活检前进行血清学检测可能更合适。
