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连续流左心室辅助装置植入后的再入院情况。

Readmissions after continuous flow left ventricular assist device implantation.

作者信息

Kimura Mitsutoshi, Nawata Kan, Kinoshita Osamu, Yamauchi Haruo, Hoshino Yasuhiro, Hatano Masaru, Amiya Eisuke, Kashiwa Koichi, Endo Miyoko, Kagami Yukie, Nemoto Mariko, Ono Minoru

机构信息

Department of Cardiac Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.

Department of Healthcare Quality Assessment, The University of Tokyo, Tokyo, Japan.

出版信息

J Artif Organs. 2017 Dec;20(4):311-317. doi: 10.1007/s10047-017-0975-4. Epub 2017 Jul 27.

Abstract

Continuous flow left ventricular assist device (CF-LVAD) therapy has improved the survival of patients with advanced heart failure. However, the readmission rate of CF-LVAD patients is still relatively high. A total of 90 patients who received CF-LVADs between April 2011 and March 2016 at our institute and were discharged home were analyzed retrospectively. They were followed up through March 2017. Clinical data, including frequency, length and etiology of readmission, were obtained from medical records. The mean observation period after initial discharge was 713 ± 322 days. In total, 73 patients (81%) had 236 readmissions, 214 unplanned and 22 planned. The overall and unplanned readmission rates were 1.34 and 1.22 per patient-year, respectively. The rate of freedom from unplanned first readmission at 1 year after initial discharge was 39%. The median interval between the previous hospital discharge and first and second readmissions was 311 and 213 days, respectively (log-rank test, p = 0.117). The rate of readmission after more than three readmissions was significantly higher than that of first or second readmission (log-rank test, p < 0.001). The most common etiology of readmission was driveline infection (DLI) (36%), followed by stroke (9%). The median length of hospital stay due to DLI was 23 days. The patients with repeated unplanned readmissions had significantly lower EuroQol 5 dimensions questionnaire utility score than those with no or just one readmission. Readmission was common in CF-LVAD patients, and the most common etiology of readmissions was DLI. The interval to the next readmission seemed shorter for patients with repeated readmissions.

摘要

持续血流左心室辅助装置(CF-LVAD)治疗提高了晚期心力衰竭患者的生存率。然而,CF-LVAD患者的再入院率仍然相对较高。对2011年4月至2016年3月在我院接受CF-LVAD治疗并出院回家的90例患者进行回顾性分析。随访至2017年3月。从病历中获取临床数据,包括再入院的频率、时长和病因。首次出院后的平均观察期为713±322天。共有73例患者(81%)发生236次再入院,其中214次为非计划性再入院,22次为计划性再入院。总体和非计划性再入院率分别为每人年1.34次和1.22次。首次出院后1年无计划首次再入院的自由度为39%。上次出院与首次和第二次再入院之间的中位间隔分别为311天和213天(对数秩检验,p=0.117)。三次以上再入院后的再入院率显著高于首次或第二次再入院(对数秩检验,p<0.001)。再入院最常见的病因是驱动线感染(DLI)(36%),其次是中风(9%)。因DLI住院的中位时长为23天。反复非计划性再入院的患者的欧洲五维健康量表效用得分显著低于无再入院或仅有一次再入院的患者。CF-LVAD患者再入院很常见,再入院最常见的病因是DLI。反复再入院的患者下次再入院的间隔似乎更短。

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