Bell L, Lamport D J, Butler L T, Williams C M
School of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights Road, Reading, RG6 6AL, UK.
Food Funct. 2017 Sep 20;8(9):3104-3110. doi: 10.1039/c7fo00724h.
The postprandial response to ingested carbohydrate is recognised as a marker of metabolic health. Postprandial hyperglycaemia is observed in type 2 diabetes mellitus and is a significant risk factor for cardiovascular disease. Cognitive deficits are also associated with type 2 diabetes. Therefore interventions which moderate postprandial glucose profiles are desirable. Here we investigated the impact of anthocyanin-rich wild blueberries on postprandial glucose response. Seventeen healthy young adults consumed a range of doses of freeze-dried wild blueberry powder, in smoothie form, in both sugar-matched and no-added-sugar conditions. Plasma glucose was determined by a capillary sampling method at baseline and at regular intervals up to 2.5 hours postprandially. Blueberries were observed to significantly extend the postprandial glucose response beyond the period observed for a sugar-matched control, characteristic of a beneficial glycaemic response. Furthermore, blueberries were observed to reduce peak postprandial glucose levels, although statistical significance was not achieved. The findings suggest a tempering of the postprandial glucose response in the presence of anthocyanin-rich blueberry, and are discussed with reference to likely glucoregulatory mechanisms of action and their implications for cognitive and type 2 diabetes research.
餐后对摄入碳水化合物的反应被认为是代谢健康的一个指标。2型糖尿病患者会出现餐后高血糖，这是心血管疾病的一个重要危险因素。认知缺陷也与2型糖尿病有关。因此，适度调节餐后血糖水平的干预措施是可取的。在此，我们研究了富含花青素的野生蓝莓对餐后血糖反应的影响。17名健康的年轻成年人以奶昔形式食用了一系列剂量的冻干野生蓝莓粉，分别处于糖匹配和无糖添加的条件下。通过毛细血管采样法在基线时以及餐后2.5小时内定期测定血浆葡萄糖。观察到蓝莓能显著延长餐后血糖反应时间，超过了糖匹配对照组所观察到的时间，这是有益的血糖反应的特征。此外，观察到蓝莓可降低餐后血糖峰值水平，尽管未达到统计学显著性。这些发现表明，在富含花青素的蓝莓存在的情况下，餐后血糖反应会得到缓和，并参考可能的血糖调节作用机制及其对认知和2型糖尿病研究的意义进行了讨论。
