Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Korea.
Department of Obstetrics and Gynecology, Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine, Seoul 04619, Korea.
Nutrients. 2017 Jul 19;9(7):772. doi: 10.3390/nu9070772.
We evaluated the effect of red ginseng on toxicity, health-related quality of life (HRQL) and survival after adjuvant chemotherapy in patients with epithelial ovarian cancer (EOC). A total of 30 patients with EOC were randomly assigned to placebo ( = 15) and red ginseng groups ( = 15). All patients took placebo or red ginseng (3000 mg/day) for three months. Then, we compared changes of genotoxicity, HRQL and survival between the two groups. As a result, red ginseng reduced micronuclei yield in comparison with placebo despite no difference of binucleated cells index. Although red ginseng increased serum levels of alanine aminotransferase and aspartate aminotransferase significantly, they were within the normal value. Moreover, there were no differences in adverse events between placebo and red ginseng groups. In terms of HRQL, red ginseng was associated with improved emotional functioning and decreased symptoms of fatigue, nausea and vomiting, and dyspnea, reduced anxiety and interference affecting life and improved daytime somnolence. However, there was no effect of red ginseng on prognosis of EOC. Conclusively, red ginseng may be safe and effective to reduce genotoxicity and improve HRQL despite no benefit of survival in patients with EOC who received chemotherapy.
我们评估了红参对上皮性卵巢癌（EOC）患者辅助化疗后毒性、健康相关生活质量（HRQL）和生存的影响。共 30 例 EOC 患者随机分为安慰剂组（n = 15）和红参组（n = 15）。所有患者均服用安慰剂或红参（3000mg/天）3 个月。然后，我们比较了两组之间遗传毒性、HRQL 和生存的变化。结果显示，尽管双核细胞指数无差异，但红参组的微核产量低于安慰剂组。虽然红参组的丙氨酸氨基转移酶和天冬氨酸氨基转移酶血清水平显著升高，但仍在正常值范围内。此外，安慰剂组和红参组的不良事件无差异。在 HRQL 方面，红参可改善情绪功能，减轻疲劳、恶心呕吐和呼吸困难症状，降低焦虑和影响生活的干扰，改善白天嗜睡。然而，红参对 EOC 的预后没有影响。总之，红参可能对接受化疗的 EOC 患者安全且有效，可降低遗传毒性，改善 HRQL，但对生存无获益。
