Shi Yu-Sheng, Zhang Yan, Hu Wen-Zhong, Chen Xi, Fu Xin, Lv Xia, Zhang Li-Hong, Zhang Ning, Li Guang
Key Laboratory of Biotechnology and Bioresources Utilization, Educational of Minister, College of Life Science, Dalian Nationalities University, Dalian 116600, China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Molecules. 2017 Jul 19;22(7):1206. doi: 10.3390/molecules22071206.
A new triterpene glycoside ilexdunnoside A () and a new sulfated triterpene derivative ilexdunnoside B (), together with five known analogues - were isolated from the roots of Levl. The structures were established by NMR spectroscopic analysis and acid hydrolysis. Results of an in vivo study of the biological activity showed that 75% ethanol and -butanol extracts of the plant displayed anti-inflammatory activities against ear edema in mice, with inhibition rates of 23.5% and 37.5%, respectively, at a dose of 50 mg/kg. Furthermore, Compounds , and exhibited moderate indirect inhibitory effects on lipopolysaccharide-induced NO production in BV2 microglial cells in vitro, with IC values of 11.60, 12.30 and 9.70 μM, respectively.
从粗毛冬青（Ilex strigillosa Levl.）的根中分离得到一个新的三萜糖苷类化合物粗毛冬青苷A（）和一个新的硫酸化三萜衍生物粗毛冬青苷B（），以及五个已知类似物。通过核磁共振光谱分析和酸水解确定了它们的结构。体内生物活性研究结果表明，该植物75%乙醇提取物和正丁醇提取物对小鼠耳部水肿具有抗炎活性，在剂量为50 mg/kg时，抑制率分别为23.5%和37.5%。此外，化合物、和在体外对BV2小胶质细胞中脂多糖诱导的NO产生表现出中等程度的间接抑制作用，IC值分别为11.60、12.30和9.70 μM。
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