Four new triterpenes and triterpene glycosides from the leaves of Ilex latifolia and their inhibitory activity on triglyceride accumulation.

作者信息

Wang Cun-Qin, Li Man-Mei, Zhang Wei, Wang Lei, Fan Chun-Lin, Feng Rui-Bing, Zhang Xiao-Qi, Ye Wen-Cai

机构信息

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China; College of Pharmacy, Wannan Medical College, Wuhu 241000, People's Republic of China.

Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, People's Republic of China.

出版信息

Fitoterapia. 2015 Oct;106:141-6. doi: 10.1016/j.fitote.2015.09.003. Epub 2015 Sep 5.

DOI:10.1016/j.fitote.2015.09.003

PMID:26347952

Abstract

Two new triterpenes (1 and 2) and two new triterpene glycosides (3 and 4), along with six known triterpenes (5-10) were isolated from the leaves of Ilex latifolia. The structures of new compounds were elucidated on the basis of NMR, HR-MS, and X-ray diffraction analysis. Compounds 4 and 5 showed potent inhibitory activity on oleic acid/palmitic acid induced triglyceride accumulation on HepG2 cells.

摘要