Huang Xiao-Jun, Wen Si, Guan Xi-Feng, Wu Zhen-Long, Li Man-Mei, Fan Chun-Lin, Zhang Qing-Wen, Chan Ging, Wang Ying, Ye Wen-Cai
Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, P. R. China.
Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Jinan University, Guangzhou, 510632, P. R. China.
Chem Biodivers. 2019 Jul;16(7):e1900202. doi: 10.1002/cbdv.201900202. Epub 2019 Jun 12.
Asprellosides A-K, nine new ursane-type triterpenoid glycosides (1-9), and two new oleanane-type triterpenoid glycosides (10 and 11), including six rare sulfated triterpenoid glycosides, were isolated from the roots of Ilex asprella. Their structures were determined on the basis of comprehensive spectroscopic analysis and chemical methods. Among these compounds, asprelloside B (2) and asprelloside C (3) are the first examples of triterpenoid glycosides bearing a rare 3,4-O-disulfo-xylopyranosyl residue. All the saponins isolated showed no significant effects against respiratory syncytial virus (RSV) and lipopolysaccharide-induced nitric oxide production in Raw264.7 macrophages.
从岗梅根中分离得到了9个新的乌苏烷型三萜糖苷（1-9）——蛇根草皂苷A-K，以及2个新的齐墩果烷型三萜糖苷（10和11），其中包括6个罕见的硫酸化三萜糖苷。通过综合光谱分析和化学方法确定了它们的结构。在这些化合物中，蛇根草皂苷B（2）和蛇根草皂苷C（3）是首次发现的带有罕见的3,4-O-二磺基吡喃木糖基残基的三萜糖苷实例。所有分离得到的皂苷对呼吸道合胞病毒（RSV）以及脂多糖诱导的Raw264.7巨噬细胞中一氧化氮的产生均无显著影响。
