a Laser Biomedical Applications Section , Raja Ramanna Centre for Advanced Technology , Indore , India.
Artif Cells Nanomed Biotechnol. 2018 Aug;46(5):1009-1017. doi: 10.1080/21691401.2017.1358731. Epub 2017 Jul 28.
Curcumin is a promising wound healing agent but its clinical application is limited due to hydrophobicity and lack of stability. In this article, we report the results of a study on wound healing efficacy of curcumin conjugated to hyaluronic acid (HA) which is a natural polysaccharide known to influence the healing process. Studies on proliferation, antioxidant activity and scratch wound healing carried out in human keratinocyte cells revealed that HA-conjugated curcumin treatment enhanced cell proliferation, decreased oxidative damage induced by HO and also improved migration of cells in scratch wounds as compared to treatment with native curcumin. HA conjugated curcumin exhibited bactericidal activity in dark and phototoxicity when irradiated with blue light against antibiotic resistant bacteria. Furthermore, wound healing efficacy studied in diabetic mice demonstrated that topical application of the conjugate on wounds led to better healing as compared to treatment with HA-free curcumin and HA alone. These results suggest that HA conjugation is a promising formulation of curcumin for enhancing its healing efficacy.
姜黄素是一种很有前途的伤口愈合剂，但由于其疏水性和不稳定性，其临床应用受到限制。在本文中，我们报告了将姜黄素与透明质酸（HA）偶联用于伤口愈合效果的研究结果，HA 是一种天然多糖，已知会影响愈合过程。在人角质形成细胞中进行的增殖、抗氧化活性和划痕伤口愈合研究表明，与天然姜黄素相比，HA 偶联姜黄素处理增强了细胞增殖，减少了 HO 诱导的氧化损伤，并且还改善了划痕伤口中的细胞迁移。HA 偶联姜黄素在黑暗中和蓝光照射下表现出光毒性，对耐药菌具有杀菌活性。此外，在糖尿病小鼠中进行的伤口愈合效果研究表明，与不含 HA 的姜黄素和 HA 单独处理相比，将该偶联物局部应用于伤口可导致更好的愈合。这些结果表明，HA 偶联是增强姜黄素愈合效果的一种很有前途的制剂。
