Çetin Deniz, Tanrıverdi Özgür, Solak Özşeker Havva, Özşeker Burak
Muğla Sıtkı Koçman University Faculty of Medicine, Department of Internal Medicine, 48000, Muğla, Turkey.
Muğla Sıtkı Koçman University Faculty of Medicine, Department of Medical Oncology, Muğla, Turkey.
Clin J Gastroenterol. 2017 Oct;10(5):474-477. doi: 10.1007/s12328-017-0766-8. Epub 2017 Jul 28.
Celiac disease (CD) is a chronic immune-mediated enteropathy which is triggered by dietary gluten in genetically predisposed individuals. Increased risk of all gastrointestinal cancers was found during the first year after diagnosis of CD. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous tumor group originating from the diffuse neuroendocrine system. Today, the incidences of both GEP-NETs and CD have increased due to the increased availability of diagnostic tools and awareness. Association of GEP-NETs with CD is rarely seen. Here we aimed to present a case in which we diagnosed CD with concurrent rectal NET. Association of CD and rectal NET has not been reported in the literature, and we believe that our case report can contribute to the epidemiological data.
乳糜泻(CD)是一种慢性免疫介导的肠病,由遗传易感性个体摄入膳食麸质引发。在CD诊断后的第一年发现所有胃肠道癌症的风险增加。胃肠胰神经内分泌肿瘤(GEP-NETs)是一组起源于弥漫性神经内分泌系统的异质性肿瘤。如今,由于诊断工具的可及性提高和认知度增加,GEP-NETs和CD的发病率均有所上升。GEP-NETs与CD的关联很少见。在此,我们旨在介绍一例同时诊断为CD和直肠神经内分泌肿瘤(NET)的病例。CD与直肠NET的关联在文献中尚未见报道,我们相信我们的病例报告可为流行病学数据提供补充。