Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, San Luis Potosi, S.L.P., Mexico.
Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Av. Venustiano Carranza 2405, Los Filtros, San Luis, S.L.P., Mexico.
Nanomedicine. 2017 Nov;13(8):2587-2596. doi: 10.1016/j.nano.2017.07.007. Epub 2017 Jul 26.
Silver nanoparticles (AgNPs) are promising antibacterial nanomaterials for diagnostic and treatment of diabetes. However, toxicity and adverse cardiac responses induced by AgNPs related to nitric oxide (NO) and oxidative stress (OS) are described. Moreover, little is known about the diabetes influence upon AgNPs-toxicity. The aim of this work was to evaluate cardiovascular function in response to AgNPs through measuring perfusion pressure (PP) and left ventricle pressure (LVP), using perfused hearts from streptozotocin (STZ)-induced diabetic rats and identify the role of NO and OS. High concentrations but not the lower concentrations of AgNPs, promotes increases in PP and LVP, as well as increased OS. Additionally, diabetes alters the classic effects of phenylephrine (Phe) and acetylcholine (ACh). These data suggest that diabetes may intensify AgNPs-cardiotoxicity. Nevertheless, the precise mechanism of action is still under elucidation.
银纳米颗粒（AgNPs）是一种很有前途的抗菌纳米材料，可用于糖尿病的诊断和治疗。然而，据报道，AgNPs 会引起一氧化氮（NO）和氧化应激（OS）相关的毒性和心脏不良反应。此外，关于糖尿病对 AgNPs 毒性的影响知之甚少。本研究旨在通过测量灌流心脏的灌注压（PP）和左心室压力（LVP），评估 AgNPs 对心血管功能的影响，使用链脲佐菌素（STZ）诱导的糖尿病大鼠的灌流心脏，并确定 NO 和 OS 的作用。AgNPs 的高浓度而非低浓度会促进 PP 和 LVP 的增加，以及 OS 的增加。此外，糖尿病改变了苯肾上腺素（Phe）和乙酰胆碱（ACh）的经典作用。这些数据表明，糖尿病可能会加剧 AgNPs 的心脏毒性。然而，其确切的作用机制仍在阐明之中。
