Fu Si-ling, Zhao Wan-ying, Zhang Wen-jing, Song Hai, Ji Hong-bin, Tang Nan
1. National Institute of Biological Sciences, Beijing 102206, China; 2. Graduate School of Peking Union Medical College, Beijing 100005, China.
1. National Institute of Biological Sciences, Beijing 102206, China; 2. School of Life Science,Tsinghua University, Beijing 100084, China.
Yi Chuan. 2017 Jul 20;39(7):597-606. doi: 10.16288/j.yczz.17-056.
function between the circulation and the atmospheric environment. Lung diseases, including lung cancer, are among the leading causes of death in the modern society. Research on lung development, regeneration and cancer could provide significant insights for the development of therapeutic approaches on lung diseases. Hippo/YAP/TAZ signaling pathway regulates cell proliferation and differentiation, controls organ size, and plays an important role in response to mechanical forces. YAP/TAZ are expressed in many cell types and serve various regulatory functions in the embryonic and adult lungs. In this review, we mainly focus on the roles of Hippo/YAP/TAZ signaling pathway in embryonic lung development, regeneration and cancer. We postulate that Hippo/YAP/TAZ signaling may play potential roles in regulating the alveolar mechanics and immune responses in the lung.
循环系统与大气环境之间的功能。包括肺癌在内的肺部疾病是现代社会主要的死亡原因之一。对肺发育、再生和癌症的研究可为肺部疾病治疗方法的开发提供重要见解。Hippo/YAP/TAZ信号通路调节细胞增殖和分化，控制器官大小，并在对机械力的反应中起重要作用。YAP/TAZ在多种细胞类型中表达，并在胚胎和成年肺中发挥各种调节功能。在本综述中，我们主要关注Hippo/YAP/TAZ信号通路在胚胎肺发育、再生和癌症中的作用。我们推测，Hippo/YAP/TAZ信号可能在调节肺中的肺泡力学和免疫反应方面发挥潜在作用。
