河马通路在乳腺癌发生、预后及治疗中的作用：一项系统综述
The Role of the Hippo Pathway in Breast Cancer Carcinogenesis, Prognosis, and Treatment: A Systematic Review.
作者信息
Kyriazoglou Anastasios, Liontos Michalis, Zakopoulou Roubini, Kaparelou Maria, Tsiara Anna, Papatheodoridi Alkistis Maria, Georgakopoulou Rebecca, Zagouri Flora
机构信息
Department of Clinical Therapeutics, General Hospital Alexandra, Athens, Greece.
出版信息
Breast Care (Basel). 2021 Feb;16(1):6-15. doi: 10.1159/000507538. Epub 2020 May 12.
Abstract
BACKGROUND
The Hippo pathway is a developmental pathway recently discovered in ; in mammals it normally controls organ development and wound healing. Hippo signaling is deregulated in breast cancer (BC). MST1/2 and LATS1/2 kinases are the upstream molecular elements of Hippo signaling which phosphorylate and regulate the two effectors of Hippo signaling, YAP1 and TAZ cotranscriptional activators. The two molecular effectors of the Hippo pathway facilitate their activity through TEAD transcription factors. Several molecular pathways with known oncogenic functions cross-talk with the Hippo pathway.
METHODS
A systematic review studying the correlation of the Hippo pathway with BC tumorigenesis, prognosis, and treatment was performed.
RESULTS
Recent literature highlights the critical role of Hippo signaling in a wide spectrum of biological mechanisms in BC.
DISCUSSION
The Hippo pathway has a crucial position in BC molecular biology, cellular behavior, and response to treatment. Targeting the Hippo pathway could potentially improve the prognosis and outcome of BC patients.
摘要
背景
河马通路是最近在[具体物种或研究背景未提及]中发现的一条发育通路；在哺乳动物中，它通常控制器官发育和伤口愈合。河马信号在乳腺癌（BC）中失调。MST1/2和LATS1/2激酶是河马信号的上游分子元件，它们磷酸化并调节河马信号的两个效应器，即YAP1和TAZ共转录激活因子。河马通路的这两个分子效应器通过TEAD转录因子促进其活性。几条具有已知致癌功能的分子通路与河马通路相互作用。
方法
进行了一项系统综述，研究河马通路与BC肿瘤发生、预后和治疗的相关性。
结果
近期文献强调了河马信号在BC广泛生物学机制中的关键作用。
讨论
河马通路在BC分子生物学、细胞行为和治疗反应中具有关键地位。靶向河马通路可能会改善BC患者的预后和治疗结果。
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