评估低风险女性人群常规筛查[具体疾病未提及]的必要性：一项针对克罗地亚女性的患病率及合并感染研究
Assessing the Need for Routine Screening for in the Low-risk Female Population: A Prevalence and Co-infection Study on Women from Croatia.
作者信息
Ljubin-Sternak Sunčanica, Meštrović Tomislav, Kolarić Branko, Jarža-Davila Neda, Marijan Tatjana, Vraneš Jasmina
机构信息
Clinical Microbiology Department, Teaching Institute of Public Health "Dr. Andrija Štampar", Zagreb, Croatia.
Medical Microbiology Department, School of Medicine, University of Zagreb, Zagreb, Croatia.
出版信息
Int J Prev Med. 2017 Jul 4;8:51. doi: 10.4103/ijpvm.IJPVM_309_16. eCollection 2017.
BACKGROUND
There is an ongoing debate regarding possible cost and benefits, but also harm of universal screening for the emerging sexually transmitted pathogen .
METHODS
From the initial pool of 8665 samples that were tested, a subset of -positive and randomly selected -negative cervical swabs were further interrogated for by real-time polymerase chain reaction, using a 224 bp long fragment of the glyceraldehyde-3-phosphate dehydrogenase gene.
RESULTS
was detected in 4.8% of -positive samples and none of -negative samples. Accordingly, a significant association was shown between and ( < 0.01), but also between and infection ( < 0.01).
CONCLUSIONS
Based on the results, routine screening is recommended only for women with one or more identified risk factors. Moreover, younger age does not represent an appropriate inclusion/exclusion criterion for testing in the low-risk female population.
背景
关于新型性传播病原体的普遍筛查可能存在的成本效益以及危害，目前仍在进行辩论。
方法
从最初检测的8665份样本中，选取一部分阳性和随机选择的阴性宫颈拭子，使用甘油醛-3-磷酸脱氢酶基因的224bp长片段，通过实时聚合酶链反应进一步检测。
结果
在4.8%的阳性样本中检测到，阴性样本中均未检测到。因此，与之间显示出显著关联（<0.01），与感染之间也显示出显著关联（<0.01）。
结论
基于这些结果，建议仅对有一个或多个已确定风险因素的女性进行常规筛查。此外，在低风险女性人群中，年龄较小并不代表进行检测的合适纳入/排除标准。
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