Department of Biomedical Laboratory Science, Dankook University College of Health Sciences, Chungnam, Korea.
Department of Health Administration, Dankook University College of Health Sciences, Chungnam, Korea.
J Clin Lab Anal. 2022 Oct;36(10):e24682. doi: 10.1002/jcla.24682. Epub 2022 Aug 29.
Sexually transmitted infections (STIs) can have serious consequences, and the global STI incidence remains high. However, there is little information on the frequency of STIs with multiple pathogens according to age. Accordingly, we conducted a study to determine the trends of coinfection with sexually transmitted pathogens according to age in the Republic of Korea from 2018 to 2020.
From January 2018 to December 2020, 65,191 samples of swab, urine, and other types submitted for STI screening were obtained from U2Bio Co. Ltd. (Seoul, Republic of Korea). Multiplex polymerase chain reaction, a sensitive and rapid method for simultaneous detection of STIs caused by multiple different pathogens, was performed using an AccuPower STI4C-Plex Real-Time PCR kit, AccuPower STI8A-Plex Real-Time PCR kit, and AccuPower STI8B-Plex Real-Time PCR kit with an Exicycler 96 Real-Time Quantitative Thermal Block.
Of the 65,191 samples tested, 35,366 (54.3%) tested positive for one or more sexually transmitted pathogens. The prevalence of coinfections with two or more sexually transmitted pathogens was inversely proportional to age. Furthermore, the rates of coinfection with sexually transmitted pathogens and age distribution differed according to sex and the sexually transmitted pathogen type.
This study confirmed that a significant proportion of patients with STIs are coinfected with multiple pathogens. Public health managers could use these results to recognize and prevent STIs according to age.
性传播感染（STI）可能会产生严重后果，全球 STI 发病率仍然很高。然而，根据年龄对多种病原体 STI 的频率知之甚少。因此，我们进行了一项研究，以确定 2018 年至 2020 年韩国根据年龄的性传播病原体合并感染的趋势。
2018 年 1 月至 2020 年 12 月，从 U2Bio Co.，Ltd.（韩国首尔）获得了 65191 份用于性传播感染筛查的拭子、尿液和其他类型的样本。使用 AccuPower STI4C-Plex Real-Time PCR 试剂盒、AccuPower STI8A-Plex Real-Time PCR 试剂盒和 AccuPower STI8B-Plex Real-Time PCR 试剂盒，结合 Exicycler 96 实时定量热块，采用一种敏感且快速的多重聚合酶链反应方法，同时检测由多种不同病原体引起的 STI。
在 65191 个测试样本中，35366 个（54.3%）样本对一种或多种性传播病原体呈阳性。合并感染两种或两种以上性传播病原体的比例与年龄成反比。此外，合并感染性传播病原体的比例和年龄分布因性别和性传播病原体类型而异。
本研究证实，相当一部分性传播感染患者合并感染了多种病原体。公共卫生管理者可以根据年龄使用这些结果来识别和预防性传播感染。
