血管内皮生长因子基因多态性与不同类型糖尿病视网膜病变易感性的关联：系统评价和荟萃分析。
Associations between Vascular Endothelial Growth Factor Gene Polymorphisms and Different Types of Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis.
机构信息
Shenzhen Center for Chronic Disease Control, 2021 Buxin Road, Luohu District Shenzhen 518020, China.
Department of Epidemiology and Health Statistics, XiangYa School of Public Health, Central South University, Changsha, China.
出版信息
J Diabetes Res. 2021 Jan 4;2021:7059139. doi: 10.1155/2021/7059139. eCollection 2021.
BACKGROUND
Vascular endothelial growth factor () gene polymorphisms have been shown to be associated with the risk of diabetic retinopathy (DR), but the results were inconsistent. The aim of this study was to systematically assess the associations between gene polymorphisms and different types of DR (nonproliferative DR and proliferative DR).
METHODS
Electronic databases PubMed, Embase, Web of Science, CNKI, and WANFANG DATA were searched for articles on the associations between gene polymorphisms and different types of DR up to November 6, 2019. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and subgroup analyses were conducted by ethnicity. Sensitivity analysis was conducted to assess the stability of the results. Publication bias was assessed by using the Egger regression asymmetry test and visualization of funnel plots. A systematic review was conducted for polymorphisms with a high degree of heterogeneity ( > 75%) or studied in only one study.
RESULTS
A total of 13 and 18 studies analyzed the associations between SNPs and nonproliferative DR (NPDR) as well as proliferative DR (PDR), respectively. There were significant associations between rs2010963 and NPDR in Asian (dominant model: OR = 1.29, 95%CI = 1.04 - 1.60); and rs2010963 is associated with PDR in total population (dominant model: OR = 1.20, 95%CI = 1.03 - 1.41), either Asian (recessive model: OR = 1.57, 95%CI = 1.04 - 2.35) or Caucasian (recessive model: OR = 1.83, 95%CI = 1.28 - 2.63). Rs833061 is associated with PDR in Asian (recessive model: OR = 1.58, 95%CI = 1.11 - 2.26). Rs699947 is associated with NPDR in the total population (dominant model: OR = 2.04, 95%CI = 1.30 - 3.21) and associated with PDR in Asian (dominant model: OR = 1.72, 95%CI = 1.05 - 2.84).
CONCLUSIONS
Rs2010963, rs833061, and rs699947 are associated with NPDR or PDR, which may be involved in the occurrence and development of DR.
背景
血管内皮生长因子（VEGF）基因多态性与糖尿病视网膜病变（DR）的风险相关，但结果不一致。本研究旨在系统评估 VEGF 基因多态性与不同类型 DR（非增殖性 DR 和增殖性 DR）之间的关联。
方法
截至 2019 年 11 月 6 日，我们检索了电子数据库 PubMed、Embase、Web of Science、CNKI 和 WANFANG DATA 中关于 VEGF 基因多态性与不同类型 DR 之间关联的文章。计算合并优势比（OR）和 95%置信区间（CI），并按种族进行亚组分析。采用 Egger 回归不对称检验和漏斗图可视化来评估结果的稳定性。对异质性较高（ > 75%）或仅研究一项的多态性进行系统评价。
结果
共有 13 项和 18 项研究分别分析了 VEGF SNPs 与非增殖性 DR（NPDR）和增殖性 DR（PDR）之间的关联。rs2010963 与亚洲人群的 NPDR 之间存在显著关联（显性模型：OR=1.29，95%CI=1.04-1.60）；rs2010963 与总体人群的 PDR 相关（显性模型：OR=1.20，95%CI=1.03-1.41），无论是亚洲人（隐性模型：OR=1.57，95%CI=1.04-2.35）还是高加索人（隐性模型：OR=1.83，95%CI=1.28-2.63）。rs833061 与亚洲人群的 PDR 相关（隐性模型：OR=1.58，95%CI=1.11-2.26）。rs699947 与总体人群的 NPDR 相关（显性模型：OR=2.04，95%CI=1.30-3.21），与亚洲人群的 PDR 相关（显性模型：OR=1.72，95%CI=1.05-2.84）。
结论
rs2010963、rs833061 和 rs699947 与 NPDR 或 PDR 相关，这可能与 DR 的发生和发展有关。
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