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高效皮秒激光用于去除大鼠模型中的纹身。

Efficient Picosecond Laser for Tattoo Removal in Rat Models.

机构信息

Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China (mainland).

Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, Shandong, China (mainland).

出版信息

Med Sci Monit. 2020 Jul 25;26:e924583. doi: 10.12659/MSM.924583.

DOI:10.12659/MSM.924583
PMID:32709839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7401794/
Abstract

BACKGROUND Tattoos are popular in modern times. Due to the occurance of adverse effects such as poor aesthetic value, scar hyperplasia, and abnormal pigments, there is a high demand for uniform operation standards as well as standards for tattoo technologies. In the present study we used Sprague-Dawley rats to assess the tattoo removal efficacy of use of a picosecond laser at various energy values. MATERIAL AND METHODS Tattoos were made on the backs of rats, then we used a picosecond laser set at various energy parameters to remove the tattoos. After performing the removal procedure in multiple groups, we selected the most suitable energy levels with corresponding parameters for the tattoo removal. We recruited human volunteers who wanted their tattoos removed and used the energy level found to perform best during tattoo removal experiments. The tattoo removal effects were evaluated and verified. Four tattoo volunteers were treated by using the optimal energy parameters for picosecond laser technology. RESULTS Through characterization observation and pathological staining results, it was demonstrated that the 1.9 mJ/μbeam energy laser had the best hollowing effect and the most complete pigment particle crushing effect in the rat skin, and had the best tattoo removal effect. CONCLUSIONS We leveraged the evaluation standard to choose the most suitable energy value of the picosecond laser, which had a good tattoo removal effect and could be employed as a reference for clinical removal of tattoos. This process provides criteria for tattoo removal evaluations as well as alternatives for tattoo removal in clinical practice.

摘要

背景

纹身如今非常流行。由于出现了不良影响，如美学价值差、疤痕增生和色素异常等，因此对于纹身技术的操作标准和规范有很高的需求。在本研究中，我们使用 Sprague-Dawley 大鼠评估了使用皮秒激光在不同能量值下的纹身去除效果。

材料与方法

在大鼠背部制作纹身，然后使用不同能量参数的皮秒激光去除纹身。在对多个组进行去除程序后，我们选择了最适合去除纹身的相应参数的最佳能量水平。我们招募了想要去除纹身的人类志愿者，并使用在纹身去除实验中表现最佳的能量水平进行治疗。评估和验证了纹身去除效果。

结果

通过特征化观察和病理染色结果表明，1.9 mJ/μbeam 能量激光在大鼠皮肤中具有最佳的空心效果和最完整的色素颗粒破碎效果，具有最佳的纹身去除效果。

结论

我们利用评估标准选择了最适合皮秒激光的能量值，该值具有良好的纹身去除效果，可作为临床去除纹身的参考。这一过程为纹身去除评估提供了标准，并为临床实践中的纹身去除提供了替代方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/d56947d0861f/medscimonit-26-e924583-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/e3909ce7df77/medscimonit-26-e924583-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/104f343c2ea1/medscimonit-26-e924583-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/7bf1fc675cc6/medscimonit-26-e924583-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/17753027293b/medscimonit-26-e924583-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/d56947d0861f/medscimonit-26-e924583-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/e3909ce7df77/medscimonit-26-e924583-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/104f343c2ea1/medscimonit-26-e924583-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/7bf1fc675cc6/medscimonit-26-e924583-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/17753027293b/medscimonit-26-e924583-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7192/7401794/d56947d0861f/medscimonit-26-e924583-g005.jpg

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J Cosmet Laser Ther. 2020;22(1):43-47. doi: 10.1080/14764172.2019.1710536. Epub 2020 Jan 3.
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A novel titanium sapphire picosecond-domain laser safely and effectively removes purple, blue, and green tattoo inks.一种新型钛宝石皮秒域激光器能安全有效地去除紫色、蓝色和绿色纹身墨水。
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Using normal and high pulse coverage with picosecond laser treatment of wrinkles and acne scarring: Long term clinical observations.
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Lasers Med Sci. 2023 Jan 12;38(1):40. doi: 10.1007/s10103-022-03702-0.
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The Picosecond Laser Effects on Tattoo Removal and Metabolic Pathways.皮秒激光对纹身去除及代谢途径的影响。
Clin Cosmet Investig Dermatol. 2021 Sep 24;14:1343-1350. doi: 10.2147/CCID.S332265. eCollection 2021.
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